Abstract
The antihepatatoxic effects of flavonolignans and related constituents from Silybum marianum were examined using carbon tetrachloride- and galactosamine-induced cytotoxicity
in primary cultured rat hepatocytes as model systems. Remarkable inhibitory actions
were observed with silandrin, 3-deoxysilychristin, silybin and silymonin in carbon
tetrachloride-treated cultures, and silydianin and silymonin were effective in preventing
galactosamine-produced cell lesions. Possible structure-activity relationships are
discussed.
1 Part 16 in the Tohoku University series on Liver-protective drugs
